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HIV-exposed but uninfected individuals at risk of obesity and asthma-like symptoms

HIV-exposed but uninfected individuals at risk of obesity and asthma-like symptoms

Researchers at the Massachusetts General Hospital (MGH) have found that adolescents and young adults who were born to mothers with HIV but are unsure of themselves are still suffering from symptoms such as obesity and asthma. Face a lot of risk. In a study published in the Journal of Acquired Immune Disease Syndrome (JADS), the team revealed for the first time that HIV-negative adolescents and young adults have a history of January's HIV exposure, obesity, and asthma. Four times as much. Symptoms compared to their unexpected peers.

Our study has found that HIV in metabolism has metabolic and immune consequences. These findings require all children of HIV-infected mothers - even those who are HIV-negative - to be continuously monitored by their health-care clinicians for their life hours. Should. Often, after exposure to HIV, their medical records show that HIV is negative.

Metabolism Unit, Department of Medicine, MGH MD Lindsay Forman, and lead author of this research.

Globally, more than one million babies are born to HIV-infected mothers every year. With prenatal antiretroviral therapy scales to prevent maternal transmission during pregnancy, 98% of these children may have HIV-exposed but non-essential (HEU). While intrauterine HIV has been actively examined to understand the short-term health consequences of HIV exposure, the long-term health consequences of non-adult adolescents are largely unknown.

MGH researchers highlighted this topic during the last quarter of pregnancy by looking at the level of mammary immune cells - known as CD4 T cells. They found that lower maternal CD4 T cell count was strongly associated with increased body mass index (BMI), a measure of height and weight-based physical fat in these offspring. CD4 T cell lowering is also associated with more severe HIV infection during pregnancy. "These contacts suggest the need for better control of the immune system during the mother's pregnancy," stresses Stephen Gurnspoon, MD, MD, chief of the metabolism unit at MGH. "Improving the immune system during pregnancy can not only be good for the mother, but also better for her baby in the long run."


This comprehensive study consists of 50 adolescents and young adults (ages 13 to 28), who were HIV-infected but non-essential (HEU), and 141 during their pregnancy. Were not affected by HIV. All research patients were part of the patients' data registry, including patients from MGH, Bergheim and Women's Hospital, and other affiliated hospitals. Researchers found that 42% of HEU youth and young adults found obesity in 42% of non-obese counterparts.

Forman noted, "It is well-known that obesity in all segments of the population is associated with hypertension, high cholesterol and insulin resistance." He added that at present an estimated 18 million HEUs are under the age of 15 worldwide. "And studies have shown that 80% of obese adults are obese as young adults." The MGH study further found that 23% of the HEU group had symptoms similar to asthma, compared to 23% of their peers.

More broadly, the MGH study can help scientists gain insights into the role of the intrauterine environment in shaping the long-term health of pregnant women. For example, Garris Spoon points out, "Fetal exposure to maternal obesity or invasive diabetes is associated with obesity, insulin resistance, asthma, and autoimmunity later in life. The results of our study give us long-term results. Teach about the effects of inflammation during pregnancy. Health-related terms. This is a fertile area for further investigation. "